Regulation of CCN1 via the 3′-untranslated region
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چکیده
منابع مشابه
Regulation of AUF1 expression via conserved alternatively spliced elements in the 3' untranslated region.
The A+U-rich RNA-binding factor AUF1 exhibits characteristics of a trans-acting factor contributing to the rapid turnover of many cellular mRNAs. Structural mapping of the AUF1 gene and its transcribed mRNA has revealed alternative splicing events within the 3' untranslated region (3'-UTR). In K562 erythroleukemia cells, we have identified four alternatively spliced AUF1 3'-UTR variants, includ...
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It has been hypothesized that both the 3'-untranslated region (3'UTR) and the 5'-untranslated region (5'UTR) of the ornithine decarboxylase (ODC) mRNA influence the expression of the ODC protein. Here, we use luciferase expression constructs to examine the influence of both UTRs in keratinocyte derived cell lines. The ODC 5'UTR or 3'UTR was cloned into the pGL3 control vector upstream or downst...
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To better characterize the increase in lipoprotein lipase (LPL) translation by hypothyroidism, adipocytes were prepared from control and hypothyroid rats. Whereas LPL synthesis was higher in hypothyroid adipocytes, with no change in mRNA levels, there was no increase in hormone-sensitive lipase (HSL) synthesis. To determine whether a transacting translation regulatory factor was present, a cyto...
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Translation termination at premature termination codons (PTCs) triggers degradation of the aberrant mRNA, but the mechanism by which a termination event is defined as premature is still unclear. Here we show that the physical distance between the termination codon and the poly(A)-binding protein PABPC1 is a crucial determinant for PTC recognition in human cells. "Normal" termination codons can ...
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-Untranslated Region ′ on the 3 Regulation of Endothelial NO Synthase mRNA Stability : RNA-Binding Proteins Crowd Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 1999 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.85.7.653 1999;85:653-655 Circ Res. h...
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ژورنال
عنوان ژورنال: Journal of Cell Communication and Signaling
سال: 2013
ISSN: 1873-9601,1873-961X
DOI: 10.1007/s12079-013-0202-x